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Description

Intermittent claudication in peripheral arterial disease In peripheral arterial disease, atherosclerosis of the arteries that supply the lower extremities may diminish blood flow to the point that the metabolic needs of exercising muscles are not sufficiently met, thereby leading to ischemic leg or hip pain known as claudication (see the page on Intermittent Claudication in Peripheral Arterial Disease) (63)

Similarly, a decline in NADP + is also expected during aging, since it is exclusively synthesized from NAD + by cytoplasmic and mitochondrial NAD + kinases 44