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(DHFR = dihydrofolate reductase

Macroautophagy (autophagy hereafter) is a process of cellular self-digestion that involves the sequestration of cytoplasmic contents into a vesicle (the autophagosome) that fuses with the lysosome where it is degraded

doi:10.1111/HEAD.70016 Doan N, Pekdemir M, Ylmaz S, et al

Hepatol Commun 4(9):12931301 Sonali S et al (2022) Mechanistic insights into the link between gut dysbiosis and major depression: an extensive review

108 This supports the hypothesis that GSTM1 may protect astrocytes from the toxic effects of dopamine metabolism, potentially by preventing harmful reductions of aminochrome

Antiestrogenic action Among the oncostatic effects of melatonin, antiestrogenic actions are instrumental, especially relevant in hormone-dependent tumors, such as breast, prostate, and ovarian cancer [49]