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Cortisone and related steroid medications are commonly prescribed to alleviate inflammation associated with a variety of conditions, including allergic reactions, skin issues, ulcerative colitis, arthritis, lupus, psoriasis, and respiratory difficulties

Interestingly, hypothalamic astrocytes from rats following sleep deprivation exhibited different proteome profiles, and the expression of VAMP2, which is an essential protein for vesicular exocytosis (Kim et al., 2014), was significantly increased

Statements Acknowledgments This work was supported by grants from University of PadovaMURST ex-60%. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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In addition, CD8+ T cells exhibited an innate-like functional impairment state characterized by low cytotoxicity and a low clonal expansion phenotype, and early-relapse tumors exhibited low proliferative capacity and high immune evasion ability