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Genetically altered mice to evaluate glutathione homeostasis in health and disease

(97) showed that the carcinogenicity of LDH-deficient tumor cells was significantly reduced and, after LDH knockdown, the metabolic phenotype of the cells was disturbed and their proliferation ability was significantly decreased

Biomedicine & Pharmacotherapy , 173 , 116324

Primary antibody (anti-GCSc 1:100 (SantaCruz, sc390811), anti-CD45 1:100 (Santa Cruz, sc1178), anti-F4/80 1:100 (Cell Signaling Technology, 70076), anti-DNA/RNA Damage 1:200 (Abcam, 62623), anti-NRF2 1:100 (Abcam, 31163) and anti-GGT1 1:200 (donated from M

In a high-heat environment, the disruption of cellular oxidative balance leads to the massive generation of ROS

Nitric oxide allows blood vessels to relax