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Knock-out of the Igf2r / M6pr resulted in increased serum and tissue levels of IGF-II and fetal overgrowth (140% of wild-type birth weight) (22)

Howie, D., Ten Bokum, A., Necula, A

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Liver-specific knockdown of GADD45 also significantly elevated the mRNA levels of additional lipogenic genes, FASN and ACC (Fig

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