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10.1136/bjsports-2018-099355 11

Similarly, authors [3] of the first double-blind, randomized, placebo-controlled clinical trial of oral glutathione (GSH) supplementation performed in healthy adult humans concluded that despite the biochemical plausibility, optimal dose, recommended timing of administration and appropriate choice of outcome measures, no significant changes were observed in oxidative stress biomarkers or erythrocyte glutathione (GSH) concentrations following 4 weeks of oral (2 x 500mg daily) glutathione (GSH) supplementation

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Notably, mitochondria harbour a labile iron pool with strong redox activity [41], positioning these organelles as a critical hub for iron-dependent oxidative metabolism