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doi:10.1016/j.ctim.2020.102533

death of heart muscle tissue due to an interruption in its blood supply Observational study - a human research study in which no experimental intervention or treatment is applied, and participants are simply observed over time Oxidative stress - a situation in which the production of reactive oxygen species exceeds the ability of an organism to eliminate or neutralize them Placebo - a chemically inactive substance Primary prevention - taking measures to prevent the onset of disease Randomized controlled trial - a human research study in which participants are assigned by chance alone to receive either an experimental agent (the treatment group) or a placebo (the control group) Reactive oxygen species (ROS) - highly unstable oxygen-containing compounds that react easily with nearby cellular structures, potentially causing damage Authors and Reviewers Originally written in May 2015 by: Giana Angelo, Ph.D

The contribution of these mechanisms (Figure 2) to health and diseases requires further study to understand the impact of UA in these areas

If the up- or down-regulation of CAC causes an increase or decrease of mitochondrial carnitine remains to be established

Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression

Four randomised studies were seen utilising intralesional verapamil and nicardipine [37,38,39,40]