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The main tissue affected during disease progression and readily accessible from joint replacement surgeries, 258 reported increased expression of MMP3, MMP9, MMP13, and ADAMTS4 in femoral head cartilage, correlating with demethylation at specific CpG sites in their promoters

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Further reading Peruzzi B, Bottaro DP (2006)

The increased collagen availability allows for more efficient tissue regeneration during rehabilitation from injuries or intense training periods

The FDA's 2026 advisory committee review treats each form as a distinct evaluation target

"Dispo 2.0"