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Minot proposed that liver may be useful in the treatment of pernicious anemia, even though it was different than the anemia induced in Whipples dogs

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The treatment of a severe deficiency is divided into two phases: High-dose restorative therapy (injection) Through injections with B12, the bodys depleted stores are replenished and blood values quickly raised Maintenance treatment (tablets/capsules or injection) Through an oral follow-up treatment, values are stabilised and maintained

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