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The three Rel members of the family, RelA (also known as p65), RelB, and cRel, have a C-terminal transcription activation domain (TAD) that serves to positively regulate gene expression

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The Cas9-Ptpn2 system selectively disrupts the Ptpn2 gene, enhancing IFN- and TNF- signaling, and promoting CD8 + T cell proliferation, thereby sensitizing tumors to immunotherapy (Yang et al

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10.1016/j.cmet.2014.04.001 Cell Metab