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Neuropharmacology 37 (12), 155361

Additionally, none of the tested compounds had shown any inhibitory effects against multidrug resistance protein 1 (MRP1)

Patients with unstable cardiovascular disease, poorly controlled hypertension, or significant hypotension may require additional monitoring or alternative therapies

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Rampant activation can be dangerous, however, so very specialized Selective PPAR Modulator (SPPARM) medications are being developed to target the system with specificity and finesse