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Competitive endogenous RNAs (ceRNAs) act as sponges for miRNAs, ceRNAs can bind to miRNAs and reduce the abundance of miRNAs in the cell, thus reducing the inhibitory effect of miRNAs on target genes

The authors would like to gratefully acknowledge the training and use of mass spectrometry instrumentation provided by Professor Perdita Barrans group at the Michael Barber centre for collaborative mass spectrometry (MBCCMS) based at the University of Manchester

RNA isolation and qPCR analysis Total RNA from skin and lungs was isolated by RNeasy Fibrous tissue mini kits (Qiagen, Germantown, MD, 74,704)