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Mice that overexpress Jak2VF in their erythroid lineage (VFEpoR mice) exhibit heightened necrosis in atherosclerotic plaque and erythrocytic ferroptosis, and VFEpoR increases erythrocyte lipid hydroperoxide and decreases antioxidant defense ability

& Matuschewski, K

Because the body stores about 1,000 to 2,000 times as much as the typical daily intake of the vitamin, it can take several years to develop clinical symptoms of vitamin B12 deficiency