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The most touted ingredients in skin care are retinol or prescription tretinoin and topical vitamin C

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Ismail Kimji, MD, FRCPC Royal College of Physicians and Surgeons of Canada Published 26 May 2026 34-minute read 10,400 words 18 peer-reviewed sources 42 inline citations Next medical review: November 2026 Eight things to know about microinfusion serum delivery Fact 01 The stratum corneum is 10 to 30 microns thick and blocks any topical molecule larger than 500 Daltons

GHK-Cu declines 60% between ages 20 and 60: this is not a cosmetic add-on

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These tissue-bound peptide molecules degrade more slowly than free circulating peptide because they are partially protected from peptidase access