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Mutations in the genes for 12( R )-LOX (ALOX12B) or LOX-3 (ALOXE3) are commonly associated with autosomal recessive congenital ichthyosis, and epidermal accumulation of 12( R )-HETE is a feature of psoriasis and ichthyosis

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Collectively, these results suggest Cys180 in GSDME is essential for caspase-3/GzmB recognition and the subsequent cleavage

Stefan Veenstra DVM explains why glutathione is so important and how liposomal uptake makes a difference