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In recent years, there has been growing interest in finding lifestyle factors, including physical exercise as a neuroprotector for improving brain health ( PPARGC1A encoding peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), pyruvate dehydrogenase kinase 4 ( PDK4 ) and myocyte enhancer factor 2A ( MEF2A ) ( Designing specific exercise protocols has been broadly categorized into two types: aerobic training with 50-80% of VO2 max or high-intensity training (HIT) with over 90% of VO2 max ( 2 The basic structure of CREB CREB was originally isolated from the brain of a rat ( 3 Methodology To explore how HIT affects the CREB functions in the brain, a literature search was done related to the topic from December 2023 to September 2024 using different scientific databases, including PubMed, Google Scholar, and Web of Science from October 1998 to September 2024

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