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Cells were treated with dIRF4-1 or its control compounds, and proliferation was measured using cell-titer glo (Promega) after 24 h incubation (n = 3) up to 100 M

The fact that colistin did not permeabilize the CM of an MCR-1-producing strain, despite harming the outer membrane of resistant bacteria, explains why the bacteria are resistant to death or lysis and can withstand exposure to polymyxin

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Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformation

Now, a team of researchers has identified the genetic mechanisms that allow these microorganisms to withstand radiation levels nearly 1,000 times higher than the lethal dose for humans