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The molecular link between mitochondrial oxidative stress/DNA damage and ferroptosis in LN (223) is also poorly defined: it is unknown whether mitochondrial dysfunction directly triggers iron overload/lipid peroxidation or indirectly by suppressing antioxidant networks (e.g., Nrf2/GPX4)

Details are provided in the Table 1

It stabilizes intestinal permeability and reduces pancreatic infection in acute experimental pancreatitis (59)

While direct studies in AP are limited, these findings suggest melatonins potential in modulating mitochondrial quality control in pancreatic inflammation