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In all KO genotypes, cFos induction in the AP and NTS was markedly blunted compared to WT mice, establishing that both AMY1R and AMY3R are necessary for transmitting cagrilintides central effects

Within the research community, Cagrilintide has drawn interest as a subject for studying amylin and calcitonin receptor signalling, energy homeostasis, and satiety pathways in pre-clinical and laboratory models including alongside GLP-1 receptor agonists