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Thus, eryptosis can occur in compromised aged erythrocytes to further speed up their clearance

From the perspective of lipid metabolism, reduced levels of sphingosine-1-phosphate (S1P) in diabetic mouse models lead to significant sphingolipid metabolic defects, which impair both autophagic function and T-cell activity (Jin et al., 2024)

Indeed, a mounting number of studies have demonstrated that RCD of erythrocytes can occur and that it is most frequently executed without recruitment of caspase-3 [19]

Ferrell, M

Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner

Following the injection, in vivo imaging was conducted using an IVIS Spectrum (PerkinElmer) at various time points: 1 h, 2 h, 4 h, 6 h, 8 h, 12 h, 24 h, and 48 h post-injection, utilizing an excitation wavelength of 780 nm and a fluorescence emission wavelength of 840 nm