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Pfaus, J., Shadiack, A., Van Soest, T., Tse, M., & Molinoff, P

doi: 10.1002/anie.200300589 27 D'HerdeK.KryskoD

doi: 10.1177/1177271918755391 17 PowersSKDeminiceROzdemirMYoshiharaTBomkampMPHyattH

PMID: 41352706 Eur J Pharmacol Alpinetin protects against myocardial ischemia-reperfusion injury by inhibiting ferroptosis and apoptosis via mitochondrial ferritin

This finding suggests that the insertion of the octanoyl group into cavity II not only contributes to the binding of the ligand, but also helps to orient the N-terminus of ghrelin to cavity I, which is critical in receptor activation