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Peroxynitrite enhances astrocytic volume-sensitive excitatory amino acid release via a src tyrosine kinase-dependent mechanism: peroxynitrite enhances EAA release

This leads to KLF4 K32/K63-linked ubiquitination and stabilization, which results in NPC 196 (Fig

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The possible transport mechanisms together with the wide tissue distribution underlie the role of OCTN2 as the major transporter responsible for the traffic of carnitine and carnitine derivatives in the intestine, distribution to several body districts and reabsorption/excretion in the kidney (Figure 2)

Only a few of the approximately 600 human E3 ligases are currently amenable to this strategy