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Bilirubin is normally present in plasma in several forms ( 198 , 199 )

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The above difference in DNA methylation status disappeared when we analyzed the blastocysts resulting from the same differently methylated groups (CMM vs OCM) of MII oocytes, which appears as an evident effect of the OCM checkpoint

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Flow cytometry For cell cycle analysis, 5 10 5 cells were harvested by trypsinization (Beyotime, China), washed twice with PBS, and then fixed with 75% ice-cold ethanol for 24 hours at 4 C