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Efficient inhibition of -secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes

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According to the previous study, CAT deficiency was associated with an increase in adipose tissue and increased levels of serum TG, suggesting a crucial role for catalase in lipid mobilization (25)

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We first performed a thermal stability assay by incubating the enzymes at different temperatures and then measuring enzyme activities via oxidation of ABTS, a commonly-used laccase substrate 32