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Inhibition of the long non-coding RNA ZFAS1 attenuates ferroptosis by sponging miR-150-5p and activates CCND2 against diabetic cardiomyopathy

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There is also growing evidence that disruption of antioxidant systems in ferroptosis contributes to the anticancer treatment of several forms of drug-resistant solid tumors (Figure 2)

Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA

Its also thought that isotretinoin can contribute to carnitine deficiency, which can explain why some of our patients experience muscle soreness while on treatment. In a study that investigated the efficacy of reducing isotretinoin-induced myalgias with L-carnitine, 40 of 230 patients who were taking isotretinoin were found to have myalgias