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43,62 In a study comparing zonisamide, topiramate, and placebo, treatment with zonisamide and topiramate each produced significant reductions in alcohol consumed per day, percent of days drinking, and percent of days with heavy drinking

However, this current coding information can be used in conjunction with the GROUPER logic, as set forth in the ICD-10 MS-DRG Definitions Manual and publicly available on our CMS website at: to review ( the MS-DRG assignment of the current code(s) and examine the potential MS-DRG assignment of the proposed code(s), to assist in formulating any public comments for submission to CMS for consideration

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While preclinical studies demonstrate promising results, clinical trials conducted thus far have yielded mixed outcomes, with some trials reporting limited or no therapeutic benefit

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