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Familial PD, often referred to as Mendelian or monogenic PD, is generally rare but plays a crucial role in PD development due to its high penetrance

Excessive ROS can also reduce the Ca 2+ sensitivity of myofibril and damage the contractile function of muscle, possibly through enzyme complexes i and iii (Ci, Ciii)-dependent and/or reduced nicotinamide adenine dinucleotide (NADPH) oxidase-dependent pathways

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doi: 10.3389/fphar.2021.600139 9 Sharifi-RadJBouyahyaAEl MenyiyNEl OmariNShahinozzamanMAra Haque OveyMet al

Reports show that the modification of TME can diminish the progression of malignancies of the lungs in animal models and lung cancer patients [38, 39] Tumor cells release a range of proteins, including growth factors and ECM-destroying proteinases, or they drive the host to produce elaborate biomolecules capable of degrading the matrix and its adhesion molecules