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Nramp5 , a key transporter protein for cadmium uptake by the root system, is located at the plasma membrane and is highly expressed in the root maturation zone, responsible for the transport of cadmium from the outside into the root cells (Sasaki et al., 2012

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Adv Med Sci 63:6878 Stern BR, Solioz M, Krewski D, Aggett P, Aw TC, Baker S, Crump K, Dourson M et al (2007) Copper and human health: biochemistry, genetics, and strategies for modeling dose-response relationships

Figure 1 The association of dysfunction in the aforementioned pathways and the effectiveness of these aforementioned treatments have been supported by the studies from others