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5.3 Senomorphics Senomorphics are a group of SASP regulators, which can alleviate renal senescence in CKD (Schroth et al., 2020) by modulating a variety of pathways, such as MAPK, mTOR, NF-B and NRF2 pathways (Piskovatska et al., 2019), reduce the production of ROS in cultured podocytes and prevent diabetes-induced renal hypertrophy (Lee et al., 2007

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24 Freeze-fracture electron microscopy demonstrated an anastomosing network of TJ strands that were superficial and deep in leaky and tight epithelia, 5,6 respectively

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