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Eur J Epidemiol

However, when targeting specific components of one-carbon metabolism, it is possible that tumours could re-wire their metabolism to compensate

Such studies will also be necessary for devising therapeutic strategies and for identifying the patients most likely to benefit from ferroptosis-targeting interventions

DOI: 10.1080/14728222.2017.1370454 20

These studies confirm that clove compounds can function in complex biological environments at subinhibitory doses, although formal clinical trials are lacking

They might be taking a high dose on paper, but only a small fraction is surviving the "first-pass metabolism" in the liver and digestive system