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Monounsaturated fatty acids are relatively less susceptible to lipid peroxidation and their integration into membrane phospholipids can inhibit ferroptosis

Guggulsterones are ligands for bile acid receptors (FXR and TGR5) and have been studied for their influence on the enzyme iodothyronine 5'-deiodinase which catalyses the peripheral conversion of T4 (storage thyroid hormone) to T3 (active thyroid hormone)

Supplementing appears to be safe in the short-term, but more research is needed on its long-term effects

1bf, Supplementary Fig

The dual receptor activity offers a synergistic approach, potentially resulting in more significant weight loss and improved metabolic outcomes compared to therapies targeting a single receptor pathway

Neurological and Cognitive Benefits Protects neurons from oxidative and ischemic injury