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40 Despite NBDHEXs promising anticancer activity, consideration should be given to the relatively low GST-target selectivity and poor water-solubility

- Supplementation shown to increase glutathione levels in red blood cells

285 Based on the above phenomena, researchers have developed therapeutic ideas to target Gln metabolism in tumor cells, increase the concentration of Gln in TME, and promote Gln metabolism in tumor-infiltrating cells

M.Berdenis van BerlekomA.van der GeestA

It is unclear whether PDTC analog-driven proteasome inhibitors have similar protein substrate targets for tumor suppression (Yu et al., 2007

3e, Supplementary Table 4)