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Single KOs were maintained through heterozygous breeding, while double KOs were bred homozygously and WT mice were age-matched controls

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The aligned XANES image series is stack of images, one per incident energy allowing the XANES of individual cells to be assessed

Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinsons disease via suppressions of CRMP2 phosphorylation and microglial activation

Overactivated M1 macrophages exacerbate inflammation through secreting pro-inflammatory cytokines, driving joint damage, whereas immunosuppressive M2 macrophages are diminished, disrupting immune equilibrium (130)

For example, vascular damage, cognitive impairment, neurological complications, congenital defects and pregnancy complications A detailed review of these mechanisms is outside the scope of this article