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Furthermore, glutamine deprivation has been observed to augment ATF4-mediated one-carbon metabolism

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This augmented height can lead to the production of pro-inflammatory cytokines such as IFN-, which promotes B cell class switching and initiates pathogenic autoantibodies production such as Immunoglobulin G (IgG) antibodies, most notably anti-dsDNA antibodies, typical lupus-characteristic markers, that induce additional inflammation and tissue damage (115, 118)

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