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Cell 141 , 107116 (2010)

The best estimates of the population prevalence of these conditions are derived from studies in national or patient registries from Sweden and Wales, United Kingdom, using diagnostic codes for EDS and joint hypermobility syndrome, the latter a prior term for hypermobile EDS, as discussed previously

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If B12 blood levels and MMA are both high, a functional B12 deficiency could be preventing B12 being useful at cell/tissue level

The high-dose vitamin preparation quickly provides the requisite energy, and is much more effective than vitamin B12 preparations in tablet form, which have to take a detour through the stomach and intestine