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GAGs are a group of polysaccharide molecules, also known as mucopolysaccharides, that create the foundational structure of the extracellular matrix (ECM), together with other components such as collagen, elastin, fibronectin, and laminin Biomechanically, the layer of GAGs functions as a hydrated gel that provides cushioning and resists compressive forces

You could argue that that failure implies that reducing IGF is irrelevant, reducing IGF is irrelevant once the tumor burden is established, reducing IGF to only 55% is irrelevant

For example, functional TGFB1 promoter polymorphisms correlate with greater circulating TGF-1, adverse clinical features, and dismal survival trajectory in patients with brain malignancies (59)

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JAMA 329, 19341946 (2023)