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We run the GSH program and the APAP program together - they share the substrate GSH, which is drawn down by the overdose and replenished by the GSH synthesis pathway

Notably, when combined with anti-PD-L1 treatment, a synergistic effect is observed, leading to a substantial potentiation of the anti-tumor immune response [209]

doi: 10.3389/fcell.2023.1339385 154 LiXYoungbloodGAhPDbH

In keeping with the reduced capacity of homocysteine-exposed endothelial cells to inhibit platelet aggregation, Lentz and collaborators demonstrated, using experimental hyperhomocysteinemia (induced by a diet depleted of folate, high in methionine, and choline-free) that the endothelial-dependent vasodilation is impaired in hyperhomocysteinemic primates