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However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

EBioMedicine 90, 104527

Our data also suggests that chelation does not seem a treatment of choice for the elimination of gadolinium

So, the average body weight of American men and women has changed dramatically even just in the past 25 years

Drugs targeting ferroptosis in lung cancer Chemical drugs Currently, there are many drugs for tumor ferroptosis, and most of them inhibit system x c and GPX4 to promote ferroptosis [53, 54, 180, 181]