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Why the extra caution

Medications Some medications can reduce B12 absorption, such as metformin (for diabetes) and proton pump inhibitors (PPIs) used to treat acid reflux

In the main body of the refrigerator, not the door

And so FDA is going to need to use a different lens. Unlike FDA approval of a new drug, which requires years of clinical trials demonstrating safety and effectiveness, placement on the 503A Bulks List answers a different regulatory question

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W.) (International Agency for Research on Cancer International Agency for Research on Cancer, 2020)