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The participation of HSP70 in the mechanisms of holding, folding, and refolding of improperly assembled proteins, as well as the disaggregation and elimination of denatured proteins accumulating under stress conditions, protects the membranes of organelles, primarily mitochondria, and the cells themselves from damage ( The HSP70 family is known to be very conserved during evolution

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Using a yeast two-hybrid screen system, found that PDZK1 regulates the functional activity of URAT1 and enhances its UA reabsorption capacity (Lu et al., 2019)