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drug exposure (area under the curve and peak concentration) was similar in those with cirrhosis and healthy participants, with the 90% confidence intervals for the adjusted ratios spanning 1

However, malnutrition and starvation are difficult to assess clinically and in particular protein-calorie malnutrition can co-exist with chronic alcohol use and with inter-current acute or chronic illness, which may independently or in concert increase the risk of paracetamol toxicity and confound the assertion that malnutrition per se increases the risk of paracetamol toxicity [6, 16, 73, 78,79,80,81,82,83]

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References Briani, Chiara, et al

Besides targeting ERK, DUSP14 directly inactivates TAB1 by dephosphorylating its Ser438 residue, inhibiting the TCR-stimulated activation of TAK1 and downstream JNK/IKK in human Jurkat T cells upon TCR signaling (Fig