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reported that 4-HNE participates in p53-mediated signaling by phosphorylating p53, inducing activation and nuclear aggregation and leading to apoptosis (43)

Furthermore, the integration of genomic and transcriptomic profiling to develop refined IFN-related gene signatures holds significant potential for pretreatment patient stratification, enabling the identification of individuals who are likely to benefit from enhanced IFN signaling, as well as those whose tumor microenvironments may already be characterized by chronic IFN exposure and associated immunosuppressive effects

The co-prescription of anticholinergic drugs with cholinesterase inhibitors, which are used to treat dementia, further complicates management, as these medications have opposing effects on cognitive function [89]

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