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Description

Int J Polym Sci

In PTC and ATC cell lines, aurora-A, a member of the aurora serine/threonine kinase family, induces glycolysis by activating 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), and the inhibition of aurora-A with its selective inhibitor, alisertib, has been shown to improve the efficacy of sorafenib in both PTC and ATC cells [77]

The two biosimilars also hold the FDAs interchangeability designation, which allows them to be substituted for their reference products without a change in the patients prescription