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Proteomics data preprocessing Proteomics data were analyzed using MaxQuant v.1.6.10.43 (ref

Excessive testosterone production in PCOS is mainly due to the increased release of luteinizing hormone by the pituitary gland and the effects of a hyperinsulinemic state on the ovaries

P = 0.001) and sperm concentration (46.52 10 6 /mL 1.80 vs

Enzyme inhibitors incorporated into sublingual formulations can protect vulnerable peptides during the absorption window

The mechanism is purely metabolic: increased energy expenditure , suppressed lipogenesis, and elevated NAD+ levels that activate sirtuins (SIRT1, SIRT3), the same longevity-associated enzymes targeted by caloric restriction

Wolosker et al., 1999)