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However, the relatively modest increase in ATP production (~22%) compared to the doubling of proton leak suggests that part of the respiratory activity may be uncoupled from ATP synthesis at the end of the study

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10.1016/j.molmet.2021.101195 7 BabaultN.Allali-HassaniA.LiF.FanJ.YueA.JuK.et al (2018)

Amino Acid Concentrations in HIV-Infected Youth Compared to Healthy Controls and Associations with CD4 Counts and Inflammation

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[7] All potential female patients are screened and counseled on this point, and effective contraception is recommended for those undergoing NAD+ therapy if applicable