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Therefore, these surviving cells can be the potential seeds for esophageal malignancy

Pro-inflammatory cytokines stimulate corticotropin-releasing hormone (CRH) secretion and impair glucocorticoid receptor signaling, resulting in diminished negative feedback and sustained hypercortisolemia

The reduction in PTMA mRNA and protein expression in DPCs verified the success of Ptma gene silencing by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and western blot

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Considering that ROS impacts the activities of epigenetic modulators 129,130,131 , it is reasonable to hypothesize that high levels of ROS generated by increased metabolic rate, gene mutation and relative hypoxia 117 perhaps explain the DNA hypomethylation and GPX7 overexpression seen in gliomas

doi: 10.1684/ejd.2015.2628