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Studies with complete reporting and rigorous design were rated as "High," while others with some limitations or missing methodological details were rated as "Medium" or "Low." To evaluate the reliability and scientific rigor of the evidence presented in this review, we conducted a methodological quality assessment of the primary clinical trials included

The treatment effect was then evaluated using Cox proportional hazard regression, with cage assignment included as a random effect and batch as a covariate, using statistical software R (version 3.4.1) with package coxme

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