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Excess androgens driven by insulin resistance blunt the progesterone and oestrogen feedback that normally regulates kisspeptin neuronal activity

Morel GR, Len ML, Uriarte M, Reggiani PC, Goya RG (2017) Therapeutic potential of IGF-I on hippocampal neurogenesis and function during aging

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Mechanism: Stimulates pulsatile GH release Increases IGF-1 without desensitizing pituitary Specifically reduces deep abdominal fat Benefits: Reduces visceral fat while maintaining or increasing lean mass Enhances insulin sensitivity and lipid metabolism Supports training capacity in overweight or aging populations Typical Dose: 2 mg subcutaneously once daily Best taken at night before bed IGF-1 LR3: Direct Muscle Growth Stimulation IGF-1 LR3 (Long Arg3) is a modified version of IGF-1 with an extended half-life, allowing for more consistent anabolic signaling

Titration The process of gradually increasing a dose over time to allow the body to adjust and minimize side effects