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The activation of the PI3K/Akt pathway can also promote an increase in HIF-1 level, which upregulates VEGF expression, and VEGF then activates the PI3K/Akt pathway through the VEGFR2 receptor on the cell membrane, thus amplifying the protective effect on neurovascular units (Karar and Maity, 2011

Interestingly, certain MPs may be metabolically processed by the human gut microbiota without causing detrimental alterations

Nitroxide antioxidant as a potential strategy to attenuate the oxidative/nitrosative stress induced by hydrogen peroxide plus nitric oxide in cultured neurons

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doi: 10.1038/s41401-022-00902-w 137

This vitamin supports amino acid metabolism, which is essential for glutathione synthesis