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The effects of arsenic exposure on neurological and cognitive dysfunction in human and rodent studies: a review

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In an interesting crosstalk between Akt and the NAD-dependent deacetylase family of Sirtuins, Sirt1 also modulates the transcriptional activity of FoxO1 (Zhao et al., 2010), and this cytoplasmic, transcription-independent function of FoxO1 requires its deacetylation by Sirt2, and is facilitated by nuclear exclusion of FoxO1 by Akt-dependent phosphorylation (Zhou et al., 2012)

Deficiency of PD-related gene PINK1 triggers hypoxia-inducible factor-1 (HIF1) stabilization both in vivo and in vitro

Thus, instead of fixing the duration of the cold exposure, you can set the number of stress waves you want to overcome